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Blood transfusions raise numerous difficulties. The most obvious one entails finding a match. Antigens which determine blood type can cause life threatening reactions among patients. Moreover,determining blood type can cost precious time in trauma cases. In addition, other undetectable diseases may contaminate blood which might contribute to further complications. Blood has a relative short life span and can spoil quickly. All of these problems have lead to research into various synthetic blood technologies. These are currently undergoing clinical trials, but maybe be available to hospitals relatively soon.
Volume expanders don’t carry out any of the key functions of human blood, but they can help with stabilization of trauma patients. The loss of pressure remains one of the most dangerous aspects of blood loss. Blood is highly oxygenated and so even a reduced amount can continue to sustain the human body in an inactive state. However, a loss of pressure reduces the ability of the heart to pump oxygenated blood around the body. Synthetic volume expanders don’t run the danger of immunologic reactions because it contains no antigens. One can maintain blood pressure through the crisis before switching to a traditional blood transfusion.
Synthetic platelets provide the next exciting field of research. Platelets help the body stop bleeding by attaching themselves around the wound until it’s closed over. Synthetic platelets can be added to an intravenous solution to help increase clotting. In addition, it has longer shelf life than traditional blood and can be stored as a powder. This increased clotting power can make all the difference from the trauma ward and operating room. Synthetic clotting agents are right around the corner, but more complex forms of synthetic blood are still off in the distance.
One of the greatest difficulties in replicating human blood lies in oxygen transportation because most materials which hold oxygen well don’t give it up well. However, there has been some success with Hemoglobin based treatments, but they’re still in clinical trials with many of the most advanced treatments being canceled to do problems with toxicity. Nevertheless, cheap synthetic blood stands as a possibility within our lifetime.




